Fetal bovine serum (FBS) is a ubiquitously used
essential supplement in cell culture media. FBS is a
cocktail of proteins, vitamins, carbohydrates, lipids,
hormones, growth factors, minerals and trace elements
and is used as an universal growth supplement
effective for most types of human and animal
(including insect) cells. The major functions of serum
in culture media are to provide:
(i) Hormonal factors stimulating cell growth and
proliferation and promoting differentiated functions.
(ii) Transport proteins carrying hormones (e.g.
transcortin), minerals and trace elements and lipids (e.g.
(iii) Attachment and spreading factors, acting as germination
points for cell attachment.
(iv) Stabilising and detoxifying factors needed to maintain
pH or to inhibit proteases either directly, such as αantitrypsin or α2-macroglobulin, or indirectly, by acting as
an unspecific sink for proteases and other (toxic) molecules.
RM10432 is sourced in Brazil which is approved for import
into the European Union by European Commission. This
serum is collected and processed in facilities registered and
inspected by the competent authority in the country of
origin. EU approved serum can be freely moved between
EU member countries and many other countries outside of
Europe where the USDA or FDA regulations are not