Downstream applications
The isolated PDCs are suitable for studies on their functional properties, e.g. antigen uptake and presentation, crosspriming of cytotoxic T cells, T cell activation or tolerance induction, or T helper cell polarization by PDCs in experimental mouse models of infection and autoimmunity.
Highly pure PDCs were isolated with Anti-mPDCA-1 MicroBeads and have been further analyzed for IDO-dependent tolerance-induction.
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Anti-mPDCA-1 MicroBeads have also been used to isolate PDCs for subsequent analysis of EBV-induced gene 3 (EBI3) expression and regulation in mouse DC subsets.
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