Overview Clone REA329 recognizes the human dendritic cell immunoreceptor (DCIR) antigen, a single-pass type II membrane protein with a single carbohydrate recognition domain which is also known as C-type lectin domain family 4 member A (CLEC4A) or lectin-like immunoreceptor (LLIR). DCIR is expressed on dendritic cells (DCs), monocytes, macrophages, B lymphocytes, and granulocytes, but not detected on NK and T cells. DCIR is strongly expressed by DC derived from blood monocytes cultured with GM-CSF and IL-4. It is mostly expressed by monocyte-related rather than Langerhans cell related DC obtained from CD34+ progenitor cells. Finally, DCIR expression is down-regulated by signals inducing DC maturation such as CD40 ligand, LPS, or TNF-α. Thus, DCIR is differentially expressed on DC depending on their origin and stage of maturation/activation. Additional information: Clone REA329 displays negligible binding to Fc receptors. Alternative names CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR Detailed product information Technical specifications Clone REA329 Clonality monoclonal Isotype recombinant human IgG1 Isotype control REA Control Antibody (S), human IgG1 Host human cell line Type of antibody Primary antibodies, Recombinant antibodies Species human Antigen DCIR Alternative names of antigen CLEC4A, CD367, CLECSF6, DDB27, HDCGC13P, LLIR Molecular mass of antigen [kDa] 28 Distribution of antigen dendritic cells, monocytes, macrophages, B cells, lymphocytes, granulocytes Entrez Gene ID 50856 RRID AB_2651506, AB_2651507, AB_2651508, AB_2651509, AB_2651510, AB_2651511, AB_2651512, AB_2651515, AB_2651516, AB_2905183, AB_2905182, AB_2651505