Microbeads
Anti-PSA-NCAM Microbeads, human, mouse, rat
Anti-PSA-NCAM MicroBeads have been developed for the positive selection or depletion of PSA-NCAM+ cells from tissue or cell culture.
Quantity
Overview
Anti-PSA-NCAM MicroBeads have been developed for the positive selection or depletion of PSA-NCAM
+
cells from tissue or cell culture.
Detailed product information
Background information
Anti-PSA-NCAM MicroBeads recognize polysialic acid (PSA), which is linked to the extracellular domain of the neural cell adhesion molecule (NCAM, CD56).
PSA-NCAM, the highly polysialated form of NCAM, is predominantly expressed in embryonic and neonatal neural tissue
. In adult mammalian brain PSA-NCAM expression is restricted mainly to areas that retain neurogenic potential, such as the subventricular zone (SVZ)
3
and the dentate gyrus of the hippocampus.
PSA-NCAM is a marker for immature neuronal-committed progenitors that are permanently generated in the SVZ and migrate along a well-defined pathway, the rostral migratory stream, into the olfactory bulb where they differentiate into GABAergic and dopaminergic interneurons.
PSA-NCAM positive neuronal precursors have been isolated from rat forebrain and from mouse SVZ tissue after depletion of A2B5
+
glial progenitor cells.
Columns
For positive selection: MS, LS, or autoMACS
®
Columns. For depletion: LD or autoMACS Columns.