Molecular Formula: C16H18N3NaO4S Molecular
Weight: 371.4 CAS No: 69-52-3
Ampicillin (D-(-)-#-Aminobenzylpenicillin sodium salt)
is a beta-lactam antibiotic with an amino group attached
to the penicillin structure. Ampicillin is effective against
Gram positive and some Gram negative bacteria. The
presence of amino group helps the antibiotic to penetrate
the outer membrane of the Gram negative bacteria.
Ampicillin inhibits the enzyme transpeptidase which is
required for cell wall synthesis. It binds to the penicillin
binding proteins and acts as an analogue of acyl-Dalanyl-D-alanine, acylating the transpeptidase enzyme.
Eventually inhibiting the cross-linking of peptidoglycan
of the cell wall, the final stage of cell wall formation, and
ultimately resulting in the lysis of the cell.
Ampicillin is used in cell culture as selective agent.
A023 is a sterile filtered solution formulated to contain
10 mg ampicillin per ml.