Microbeads
CD62L (L-selectin) MicroBeads, mouse
Mouse CD62L (L-selectin) MicroBeads were developed for the positive selection or depletion of T cell subsets from lymph nodes or spleen.
Quantity
CD62L is highly expressed on naive T cells and down-regulated upon activation. It is also expressed on a small subset of memory T cells, the central memory T cells, which can be distinguished from naive T cells by their high expression of CD44. Furthermore, CD62L is expressed on most thymocytes, naive cytotoxic T cells, B cells, dendritic cells, macrophages, NK cells, neutrophils, and eosinophils.
For isolation of CD4
+
CD62L
+
naive T cells, the CD4
+
CD62L
+
T Cell Isolation Kit II is available.
Downstream applications
Naive T cells isolated following a MultiSort strategy were used for studies on cytokine expression,
receptor signaling,
and T cell activation by different antigen-presenting cells.
Columns
For positive selection: MS, LS, XS, or autoMACS
®
Columns. For depletion: LD, D, or autoMACS Columns.