The MACS ART Annexin V System is intended for the in vitro depletion of apoptotic human spermatozoa. The system selectively depletes unwanted cells using the natural ability of Annexin V to recognize the antigen EPS (externalized phosphatidylserine) in the plasma membrane of apoptotic cells.
Phosphatidylserine-positive cells are efficiently depleted from fresh, cryopreserved, or otherwise manipulated semen samples. The yielded spermatozoa fraction may be used in subsequent operations in Assisted Reproductive Technology.
The enriched sperm populations show higher overall quality in terms of: morphology, motility, DNA fragmentation, apoptosis, cryosurvival rates, and fertilization potential.